Comparison of TOF-PET and Bremsstrahlung SPECT images of Yttrium-90: A Monte Carlo Simulation Study

Authors

  • Akihiko Takahashi Department of Health Sciences, Faculty of Medical Sciences, Kyushu University
  • Kazuhiko Himuro Division of Radiology, Department of Medical Technology, Kyushu University Hospital
  • Masayuki Sasaki Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University
  • Shingo Baba Department of Clinical Radiology, Kyushu University Hospital, Fukuoka, Japan
  • Yasuo Yamashita Division of Radiological Technology, Department of Medical Technology, Kyushu University Hospital
Abstract:

Objective(s): Yttrium-90 (90Y) is a beta particle nuclide used in targeted radionuclide therapy which is available to both single-photon emission computed tomography (SPECT) and time-of-flight (TOF) positron emission tomography (PET) imaging. The purpose of this study was to assess the image quality of PET and Bremsstrahlung SPECT by simulating PET and SPECT images of 90Y using Monte Carlo simulation codes under the same conditions and to compare them. Methods: In-house Monte Carlo codes, MCEP-PET and MCEP-SPECT, were employed to simulate images. The phantom was a torso-shaped phantom containing six hot spheres of various sizes. The background concentrations of 90Y were set to 50, 100, 150, and 200 kBq/mL, and the concentrations of the hot spheres were 10, 20, and 40 times of those of the background concentrations. The acquisition time was set to 30 min, and the simulated sinogram data were reconstructed using the ordered subset expectation maximization method. The contrast recovery coefficient (CRC) and contrast-to-noise ratio (CNR) were employed to evaluate the image qualities. Results: The CRC values of SPECT images were less than 40%, while those of PET images were more than 40% when the hot sphere was larger than 20 mm in diameter. The CNR values of PET images of hot spheres of diameter smaller than 20 mm were larger than those of SPECT images. The CNR values mostly exceeded 4, which is a criterion to evaluate the discernibility of hot areas. In the case of SPECT, hot spheres of diameter smaller than 20 mm were not discernable. On the contrary, the CNR values of PET images decreased to the level of SPECT, in the case of low concentration. Conclusion: In almost all the cases examined in this investigation, the quantitative indexes of TOF-PET 90Y images were better than those of Bremsstrahlung SPECT images. However, the superiority of PET image became critical in the case of low activity concentrations.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Comparison of TOF-PET and Bremsstrahlung SPECT Images of Yttrium-90: A Monte Carlo Simulation Study

Objectives Yttrium-90 (90Y) is a beta particle nuclide used in targeted radionuclide therapy which is available to both single-photon emission computed tomography (SPECT) and time-of-flight (TOF) positron emission tomography (PET) imaging. The purpose of this study was to assess the image quality of PET and Bremsstrahlung SPECT by simulating PET and SPECT images of 90Y using Monte Carlo simulat...

full text

Quantitative Comparison of PET and Bremsstrahlung SPECT for Imaging the In Vivo Yttrium-90 Microsphere Distribution after Liver Radioembolization

BACKGROUND After yttrium-90 ((90)Y) microsphere radioembolization (RE), evaluation of extrahepatic activity and liver dosimetry is typically performed on (90)Y Bremsstrahlung SPECT images. Since these images demonstrate a low quantitative accuracy, (90)Y PET has been suggested as an alternative. The aim of this study is to quantitatively compare SPECT and state-of-the-art PET on the ability to ...

full text

Bremsstrahlung imaging from the liver using the Monte Carlo simulation

Introduction: Most beta and gamma radiation radioisotopes used for treatment are not suitable for imaging. The bremsstrahlung images on a conventional gamma camera helped to localize the radionuclide within and outside of the lesion. Secondary scattering of gamma rays of higher energy and bremsstrahlung causes contamination in the energy window and reducing the contrast and resolution of the im...

full text

a comparison of linguistic and pragmatic knowledge: a case of iranian learners of english

در این تحقیق دانش زبانشناسی و کاربردشناسی زبان آموزان ایرانی در سطح بالای متوسط مقایسه شد. 50 دانش آموز با سابقه آموزشی مشابه از شش آموزشگاه زبان مختلف در دو آزمون دانش زبانشناسی و آزمون دانش گفتار شناسی زبان انگلیسی شرکت کردند که سوالات هر دو تست توسط محقق تهیه شده بود. همچنین در این تحقیق کارایی کتابهای آموزشی زبان در فراهم آوردن درون داد کافی برای زبان آموزان ایرانی به عنوان هدف جانبی تحقیق ...

15 صفحه اول

Performance comparison of four commercial GE discovery PET/CT scanners: A monte carlo study using GATE

  Combined PET/CT scanners now play a major role in medicine for in vivo imaging in oncology, cardiology, neurology, and psychiatry. As the performance of a scanner depends not only on the scintillating material but also on the scanner design, with regards to the advent of newer scanners, there is a need to optimize acquisition protocols as well as to compare scanner ...

full text

Assessment of Effect Technical Directional Bremsstrahlung Splitting (DBS) on Spectra and Parameters of Simulation with Monte carlo Method BEAMnrc Code (Study Monte Carlo)

Introduction: Previous studies have shown that a Monte Carlo method for the transportations photon beam in medical linear accelerator is a good way. Strip of simulation can be used to measure the dose distribution in phantoms and patients' body. EGSnrc Code is the only code written for use in the field of radiation therapy that has many subset codes that BEAMnrc code is an impo...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 6  issue 1

pages  24- 31

publication date 2018-01-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023